Pepe Cobo opens his first gallery in 1984, in Seville. La Maquina Española, starts off with a core of artists associated to the Figura Magazine (Guillermo Paneque, Federico Guzmán, Rafael Agredano, or Pepe Espaliú amongst others) who where reacting to the Spanish pictorial tradition and the stagnant state of the arts. La Maquina Española looks outside this restricted field and, given the socio-economic characteristics of the moment (Spain and its autonomies) aspires to promote the idea of an art without borders with a selection of contemporary Andalusian and foreign artists and, also, attending the most relevant art fairs of the moment: Art Basel, Chicago, FIAC, ARCO, Los Angeles and Cologne.

In 1988 he moves La Maquina Española to Madrid, which opens in January of that same year with an exhibition by northamerican artist Cindy Sherman, and where he continues developing the line of work initiated in Seville with artists like Bernard Frieze, James Lee Byars, or Jonathan Borofsky, whilst assessing important contemporary art collections.

In addition to this he created Weber, Alexander y Cobo with two of the most prominent gallerists of the moment (John Weber and Brooke Alexander), which opens in Madrid in 1991. This initiative accommodated grandiose projects – for the importance of its artists as well as for the spectacular gallery space- by international artists such as Robert Mapplethorpe, James Rosenquist, John Baldessari, Jasper Johns, Sol Lewitt or Richard Tuttle amongst others.

In 1994 he closes all galleries in Madrid and returns to Seville, where he devotes himself to Art Consulting and organizes the project Hotel y Arte in Seville, which is born in 1997 and functions until 2000.

In 1999 he opens again his gallery in Seville as Galería Pepe Cobo, continuing with his usual line of work and incorporating many new artists to the project.

In 2005, Galería Pepe Cobo moves to Madrid following the line initiated by La Maquina Española and working with contemporary national and international artists through exhibitions and by assisting to International art fairs such as Art Basel, Art Basel Miami Beach, Frieze Art Fair, The Armory Show or ARCO.

2009 means the start of Pepe Cobo’s new Project: Pepe Cobo y cía, housed in an old vehicle repair shop. Opposed to the traditional neutral cube white gallery model, this new space maintains its initial characteristics with the aim of becoming both an incentive and a challenge for new creators. Pepe Cobo has also a long curricular trajectory as a curator and he has been advisor for the Chicago Contemporary Art Fair, member of the Art Lisbon 2001 committee and of ARCO Art fair in numerous occasions.